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Reported Holdings Of The
Opaleye Management Inc

Legal Name: OPALEYE MANAGEMENT INC.

Period of report: Jun 30, 2019
Effectiveness Date: Aug 14, 2019

Security Shares Held / Principal Amount Market Value Option
Codexis Inc (192005106) 1,350,000 $24,881k
HARROW HEALTH (45323A201) 2,210,000 $19,227k
AXOGEN INC COM (05463X106) 900,000 $17,820k
EPIZYME INC (29428V104) 1,365,000 $17,131k
UNIQURE N.V. (N90064101) 205,000 $16,021k
ODONATE THERAPEUTICS INC (676079106) 425,000 $15,593k
OCULAR THERAPEUTIX INC (67576A100) 2,950,000 $12,980k
B. Riley Wealth Management, Inc. (023111206) 645,000 $12,507k
BLUEPRINT MEDICINES CORP (09627Y109) 125,000 $11,791k
CERECOR INC (15671L109) 2,185,536 $11,176k
AUDENTES THERAPEUTICS INC COM (05070R104) 280,000 $10,601k
PTC THERAPEUTICS INC (69366J200) 226,388 $10,187k
CYTOKINETICS (23282W905) 900,000 $10,125k
TG THERAPEUTICS INC (88322Q108) 1,150,000 $9,948k
EIDOS THERAPEUTICS INC (28249H104) 305,550 $9,496k
LEXICON PHARMACUTICL (528872302) 1,480,000 $9,309k
Eton Pharmaceuticals, Inc. (29772L108) 1,075,000 $8,493k
MAGENTA THERAPEUTICS INC COM (55910K108) 535,000 $7,891k
TRICIDA INC (89610F101) 195,000 $7,695k
DECIPHERA PHARMACEUTICALS IN (24344T101) 310,000 $6,991k
FIBROGEN INC (31572Q808) 150,000 $6,777k
BIOHAVEN PHARMACTL HLDG CO L (G11196105) 150,000 $6,569k
CHIMERIX INC (16934W106) 1,470,000 $6,350k
XOMA CORP DEL (98419J206) 400,000 $5,944k
AVENUE THERAPEUTICS INC (05360L205) 930,000 $5,859k
IRONWOOD PHARMACEUCL (46333X108) 525,400 $5,748k
ACADIA PHARMACEUTCLS (004225108) 200,000 $5,346k
ARVINAS INC (04335A105) 220,000 $4,838k
Vermillon Inc. (92407M206) 4,250,000 $3,783k
ZYMEWORKS INC (98985W102) 170,000 $3,744k
STRONGBRIDGE BIOPHARMA PLC (G85347105) 1,140,000 $3,568k
FORTRESS BIOTECH INC (034960Q19) 2,365,000 $3,548k
VIKING THERAPEUTICS INC COM (92686J106) 400,000 $3,320k
AIMMUNE THERAPEUTICS INC (00900T107) 130,000 $2,708k
AQUESTIVE THERAPEUTICS INC (03843E104) 590,000 $2,478k
SYNTHORX INC (87167A103) 157,600 $2,129k
RA PHARMACEUTICALS (74933V108) 51,000 $1,534k
FENNEC PHARMACEUTICALS (31447P100) 295,000 $1,180k
ARQULE INC (04269E107) 100,000 $1,101k
CRINETICS PHARMACE (22663K107) 36,000 $900k
PROTALIX BIOTHERAPEUTICS INC (74365A101) 1,000,000 $469k
AZURRX BIOPHARMA INC COM (05502L105) 145,000 $247k
BIOLINERX LTD (09071M106) 250,000 $91k

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