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Reported Holdings Of The
PALO ALTO Investors LP

Legal Name: PALO ALTO INVESTORS LP

Period of report: Jun 30, 2019
Effectiveness Date: Aug 14, 2019

Security Shares Held / Principal Amount Market Value Option
BIOMARIN PHARMACEUTICAL INC (09061G101) 2,606,485 $223,245k
INSMED INC (457669307) 7,890,917 $202,007k
ABIOMED INC (003654100) 706,354 $183,998k
Sage Therapeutics Inc (78667J108) 795,031 $145,562k
ALEXION PHARMACEUTICALS INC CO (015351109) 1,023,780 $134,095k
STAAR SURGICAL CO COM NEW PAR $0.01 (852312305) 4,237,051 $124,485k
UNITED THERAPEUTICS CORP DEL (91307C102) 1,552,792 $121,211k
AMICUS THERAPEUTICS INC (03152W109) 7,796,299 $97,298k
IMMUNOMEDICS INC (452907108) 6,676,755 $92,607k
EPIZYME INC (29428V104) 6,935,074 $87,035k
WRIGHT MEDICAL GROUP NV (NE) (N96617118) 2,771,394 $82,643k
AIMMUNE THERAPEUTICS INC (00900T107) 3,828,564 $79,711k
CLOVIS ONCOLOGY INC COM (189464100) 5,141,304 $76,451k
VANDA PHARMA (921659108) 5,055,050 $71,226k
ACADIA PHARMACEUTCLS (004225108) 2,308,803 $61,714k
ALIGN TECHNOLOGY INC (016255101) 147,505 $40,372k
EXACT SCIENCES CORP (30063P105) 314,889 $37,169k
AMAG PHARMACEUTICALS INC (00163U106) 3,375,506 $33,721k
KARYOPHARM THERAPEUTICS INC (48576U106) 5,262,263 $31,521k
Momenta Pharmaceutical Inc. (60877T100) 1,919,313 $23,895k
ALDER BIOPHARMACEUTICALS INC (014339105) 1,861,630 $21,911k
PUMA BIOTECHNOLOGY INC (74587V107) 1,405,680 $17,866k
GILEAD SCIENCES INC (375558103) 175,900 $11,884k
PROTHENA CORP PLC (G72800108) 1,108,510 $11,717k
RIGEL PHARMACEUTICL (766559603) 3,985,945 $10,403k
KALEIDO BIOSCIENCES INC (483347100) 866,666 $10,053k
CELGENE CORP (151020104) 106,883 $9,880k
DICERNA PHARMACEUTICALS INC (253031108) 331,813 $5,226k
B. Riley Wealth Management, Inc. (016259103) 3,013,793 $2,682k
ZOGENIX INC (98978L204) 29,500 $1,410k
CYTOKINETICS INC (23282W605) 123,686 $1,391k
SUNESIS PHARMACEUTICALS INC (867328700) 1,162,473 $845k
MARINUS PHARMACEUTICALS INC CO (56854Q101) 125,321 $520k
ALDEYRA THERAPEUTICS USD0.001 (01438T106) 73,500 $441k
SOPHIRIS BIO INC (83578Q209) 247,000 $209k
IDERA PHARMACEUTICALS INC (45168K405) 77,044 $206k
MINERVA NEUROSCIENCES INC (603380106) 36,319 $204k
MELINTA THERAPEUTICS INC (58549G209) 10,137 $67k
HISTOGENICS CORP (43358V109) 302,922 $58k

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